Burnout

Burnout is a state of emotional, physical, and mental exhaustion caused by excessive and prolonged stress. It occurs when you feel overwhelmed, emotionally drained, and unable to meet constant demands
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Background

male-intro@2x-8
Male age 30

Symptoms

  • Brain Fog
  • Difficult in concentrating
  • Lack of Motivation
  • Exhaustion

Background

  • DHAS from childhood
  • Previous therapy with amphetamines
  • Abuse of cannabis
Burnout BG

Diagnosis

Constant fatigue from signs of anaemia are NOT induced by iron deficiency.

Ferritin is a protein that contains iron and is the primary form of iron stored inside of the cells. AACC, 2018

The reference range of ferritin is between 30-400 ng/ml.

Patient’s ferritin level is at 114 ng/ml which is within the safe bound.

This suggests his symptoms of anaemia are NOT induced by iron deficiency.

Improved symptoms of anaemia by increasing RDW by 21%.

Red Blood Cell Distribution Width (RDW) is a measurement of the range in the volume and size of red blood cells (Medline Plus, 2018). RDW test helps to diagnose types of anaemia and other medical conditions (Healthline, 2017)

The reference range of RDW is 11-16%.

Before Treatment – March 2018

Patient’s RDW is at 10.8% which is lower than the minimum reference value. This indicates signs of anaemia.

After First Treatment– June 2018

RDW improves by 18.5% and reaches 12.8%.

After Second Treatment – November 2018

8 months later, RDW was 13.1%, a total increase of 21%, back within the normal reference range.

Micronutrients levels – Normal

To determine the root causes of patient’s symptoms, his levels of Micronutrients were assessed.

The lab results show a positive balance in his Micronutrient capacity.

A high Creatinine level indicates signs of impaired Kidney function

Creatinine is the most commonly used indicator of renal (Kidney) function. Human Metabolome Database, 2018

The reference range of Creatinine is 40–160 mg/dl.

Patient’s level of creatinine is 239 mg/dl, this is an early indication of impaired kidney function.

Causes of fatigue & lack of motivation: Low Adrenalin, Serotonin & Noradrenalin

Adrenaline is a hormone released from the adrenal glands. Its major action, together with Noradrenaline is to prepare the body for ‘fight or flight’. Society of Endocrinology, 2018

Serotonin is a neurotransmitter that regulates mood, social behaviour, appetite, digestion, sleep, memory and sexual desire. Mclntosh, 2018

The reference range is as follows:

Adrenalin 4–10 μg/g Krea | Noradrenalin 32-58 μg/g Krea | Serotonin 148-230 μg/g Krea

Low Adrenalin, Noradrenalin and Serotonin explains why the patient is fatigued and has lack of motivation.

No viral infection

Long standing fatigue can be caused by chronic hidden viral infection. In determining the root causes of patient’s symptoms, viral infections are assessed.

The lab results show that the patient is free from virus infection.

Improved inflammation indicated by a 98% reduction of CRP

C-Reactive Protein (CRP) is a substance produced by the liver in response to inflammation. Marcin, 2017

The reference range of CRP is <3 mg/l.

Before Treatment – March 2018


The patient’s CRP level is 82.3 mg/l which exceeds of the maximum reference value by 27.5 times.

After First Treatment – June 2018


After 3 months the patient’s CRP level reduced by 98% and returned to normal at 1.5 mg/l.

Outcome

This reduction in CRP level reflects that the patient’s inflammation has immensely reduced.

Alleviated infection by reduction of Monocytes by 53.4%

Monocyte is a type of white blood cell responsible for the attack and break down of germs and bacteria that enter the body. Smith, 2018

The reference range of Monocyte is between 2% to 12%.

Before Treatment – March 2018

Patient’s Monocyte level is 15.9%, exceeding reference range by 32.5%.

High levels of Monocytes indicates the presence of a chronic infection (Smith, 2018).

After First Treatment – June 2018

Patient’s Monocyte level is 6.4%, reduction of 60%.

After Second Treatment – November 2018

Patient’s Monocyte level has stabilised to 7.4%.

Outcome

Overall, it shows a 53.4% reduction in infection existing in patient’s body.

Strength restored from elevated MCHC value by increasing 0.5g/dl. Mean Corpuscular Haemoglobin Concentration (MCHC) refers to the average haemoglobin in the red blood cells. Haemoglobin is the protein molecule that carries oxygen to the tissues within the body. The normal range for MCHC is between 33-36 g/dl. Before Treatment – June 2018 The patient’s MCHC is a little under the standard at 32.0 g/dl suggesting that he has signs of deficiency in Vitamin B12. After Treatment – November 2018 The patient’s MCHC has improved, increasing 0.5 g/dl within 5 months. Outcome
 Improved MCHC allows more efficient oxygen delivery to tissues and subsequently reduces patient’s fatigue.
Reduced risk of hypothyroidism by reducing 36.5% of TSH level. Thyroid Stimulating Hormone (TSH) is commonly used as an indicator to measure Thyroid function (Medline Plus, 2017). Elevated TSH indicated inadequate level of effective thyroid hormone. The reference range of TSH is between 0.35- 2.5 μU/ml. After First Treatment – June 2018 Patient’s TSH level is at 2.82 μU/ml which exceeds the reference maximum by 13%, indicating increased risk of hypothyroidism. After Second Treatment – November 2018 The patient’s TSH level is at 1.79 μU/ml, which has reduced by 36.5% within 5 months. Outcome Normalising TSH level reduces patient’s risk of hypothyroidism and normalises thyroid hormone function.
Rebuilt stronger immune system via elevating 22 times of IFN-gamma Interferon Gamma (IFN-gamma) which is a cytokine that plays an important role in inducing and modulating an array of immune responses by promoting macrophage activation. Tau & Rothman, 1999 The reference values for: IFN-gamma Kultur 1 is >200 pg/ml. IFN-gamma Kultur 2 is >10 pg/ml. After First Treatment – June 2018 IFN-gamma Kultur 1 is at 105.8pg/ml which is 47.1% less than the minimum reference value.
 IFN-gamma Kultur 2 is at 9.2pg/ml which is 0.8pg/ml less than the minimum reference value. Low IFN-gamma indicates weak immune response. After Second Treatment – November 2018 IFN-gamma Kultur 1 increases 5.7 pg/ml to 111.5pg/ml and his IFN-gamma Kultur 2 increases 22 times. Outcome
 The elevated value of IFN-gamma indicates that the patient has rebuilt a stronger immune system with more efficient immune responses.

Improved inflammatory response via elevated TNF-alpha 
by 65.9 times

Tumour Necrosis Factor Alpha (TNF-alpha) is an inflammatory cytokine produced by macrophages and monocytes during acute inflammation. Idriss & Naismith, 2000

The reference range for TNF-alpha stimulated is between 200-1000 pg/ml.

After First Treatment – June 2018

The patient’s TNF-alpha stimulated level is 59 pg/ml, 70.5% lower than the minimum reference value, due to previous therapy with amphetamine.

Studies show that low TNF-alpha may increase disease aggravation and defective T-cell maturation. Utheim, 2014

After Second Treatment – November 2018

The patient’s TNF-alpha stimulated level is 3945 pg/ml, improving 65.9 times, returning back within the normal range.

Outcome


The improvement reflects the patient is more protected against infections, injury, viruses and bacteria.

Improve immune system via elevated IL-1b by 99.7%

Interleukin 1 Beta (IL-1b) is a mediator of inflammatory responses and involves cell growth and differentiation (NCBI, 2018; Ren & Torres, 2008).

The refence range for IL-1b is between 1000–4000 pg/ml.

After First Treatment – June 2018

The patient’s IL-1b level is at 9pg/ml, which is 991 pg/ml less than the minimum reference value. This is a result from previous therapy with amphetamines like Ritalin.

Low IL-1b indicates poor mediation of inflammatory responses and inefficient cell growth.

After Second Treatment – November 2018

The patient’s IL-1b level is 3641pg/ml, an improvement of 99.7%, returning back to within the reference range.

Outcome


This results in an overall improvement in patient’s innate immune system.

Treatment & Outcome

1st Treatment


June 2018 – 3 Types 
of MHG Supplements

Outcome
Improve symptoms of Anaemia 
by increasing RDW by 18.5%.
Improved inflammation indicated 
by a 98% reduction of CRP.
Alleviated infection by reduction 
of monocytes by 60%.

2nd treatment

November 2018 – 12 Types 
of MHG Supplements

Outcome
Improve symptoms of Anaemia by increasing RDW by 21%.
Alleviated infection by reducING monocytes by 53.4%.
Strength restored from elevated MCHC value by increasing 0.5g/dl.
Reduced risk of hypothyroidism by reducing 36.5% of TSH level.
Rebuilt stronger immune system via elevating 22 times of IFN-gamma.
Improved inflammatory response via elevated TNF-alpha by 65.9 times.
Improve immune system via elevated IL-1b by 99.7%.

Outcome


Improve symptoms of Anaemia.
Improved inflammation.
Alleviated infection.
Strength restored.
Reduced risk of hypothyroidism.
Rebuilt stronger immune system.

References

AACC (2018) Ferritin https://labtestsonline.org/tests/ferritin

Human Metabolome Database (2018) Compound Summary for CID 588 – Creatinine https://pubchem.ncbi.nlm.nih.gov/compound/creatinine#section=Top

Idriss, H.T. & Naismith, J.H. (2000) TNF Alpha And The TNF Receptor Superfamily: Structure-Function Relationships. Microscopy Research and Technique. 50(3):184-195 https://www.ncbi.nlm.nih.gov/pubmed/10891884

Marcin (2017) C-Reactive Protein Test [online] Available at: https://www.healthline.com/health/c-reactive- protein

Mclntosh, J. (2018) What is Serotonin and What Does It Do?. Medical News Today https://www.medicalnewstoday.com/kc/serotonin-facts-232248

Medline Plus (2017) TSH – Thyroid Stimulating Hormone Test https://medlineplus.gov/lab-tests/tsh-thyroid-stimulating-hormone-test/

Medline Plus (2018) RDW – Red Cell Distribution Width 
https://medlineplus.gov/lab- tests/rdw-red-cell-distribution-width/

Ren, K. & Torres, R. (2008) Role of Interleukin-1Beta During Pain And Inflammation https://www.ncbi.nlm.nih.gov/pubmed/19166877

NCBI (2018) IL1B Interleukin 1 Beta https://www.ncbi.nlm.nih.gov/gene/3553

Smith, L. (2018) What to know about high white blood cell count. Medical News Today https://www.medicalnewstoday.com/articles/315133.php

Smith, M., Segal, J., Robinson, L., Segal, R. (2018) Burnout Prevention and Treatment. Help Guide Organisation https://www.helpguide.org/articles/stress/burnout-prevention-and- recovery.htm?pdf=true

Society of Endocrinology (2018) Adrenalin http://www.yourhormones.info/hormones/adrenaline/

Tau, G. & Rothma, P. (1999) Biologic Functions of the IFN-y receptors. Allergy. 54(12):1233-1251 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154595/

Wigert, B., Agrawal, S. (2018) Employee Burnout, Part 1: The 5 Main Causes. Gallup https://www.gallup.com/workplace/237059/employee-burnout-part-main-causes.aspx

Utheim, T.P. (2014) Why Test BCG in Sjogren’s Syndrome?. The Value of BCG and TNF in Autoimmunity. https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/tumor- necrosis-factor-alpha

Advanced Cancer Research (2003) Natural killer cells and cancer
https://www.ncbi.nlm.nih.gov/pubmed/14710949

American Cancer Society (2016) Viruses that can lead to cancer
https://www.cancer.org/cancer/cancer-causes/infectious-agents/infections-that-can-lead-to-cancer/viruses.html

Billett, H.H. (1990) Haemoglobin and haematocrit. Clinical methods: the history, physical, and laboratory examinations
https://www.ncbi.nlm.nih.gov/books/NBK259/

Campo, E., Swerdlow, S.H., Harris, N.L., Pileri, S., Stein, H., Jaffe, E.S. (2011) The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Journal of American Society of Hematology. 117(19):5019-5032
https://www.ncbi.nlm.nih.gov/pmc/articles/
PMC3109529/#

Coy, J.F. (2017) EDIM-TKTL1/Apo10 blood test: an innate immune system based liquid biopsy for the early detection, characterization and targeted treatment of cancer. International Journal of Molecular Sciences. 20:18(4)
https://www.ncbi.nlm.nih.gov/pubmed/28425973

Encyclopaedia Britannica (2019) Neurotransmitter
https://www.britannica.com/science/
neurotransmitter

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Grimm, M., Schmitt, S., Teriete, P., Biegner, T., Stenzl, A., Hennenlotter, J., Muhs, H.J., Munz, A., Nadtotschi, T., Konig, K., Sanger, J., Feyen, O., Hofmann, H., Reinert, S., Coy, J.F. (2013) A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells. BMC Cancer. 4:13:569 https://www.ncbi.nlm.nih.gov/pubmed/24304513

Ko, Y.H. (2015) EBV and human cancer. Experimental & Molecular Medicine. 47(1):e130 https://www.ncbi.nlm.nih.gov/pmc/articles/
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Lange, C.A.K, Tisch-Rottensteiner, J., Bohringer, D., Gottfried, M., Schwartzkopff, J., Auw-Hadrich, C. (2012) Enhanced TKTL1 expression in malignant tumours of the ocular adnexa predicts clinical outcome. Ophthalmology. 119(9):1924- 9
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Madu, A.J., Ocheni, S., Ibegbulam, OG., Aguwa, E.N., Madu, K.A. (2013) Pattern of CD4 T-lymphocyte values in cancer patients on cytotoxic therapy. Annals of Medical and Health Science Research. 3(4):498-503
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https://www.healthline.com/health/t-cell-count

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National Cancer Institute (2018) NCI Dictionary of Cancer Terms – thrombocytes
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National Kidney Foundation (2017) Creatinine: what is it?
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* The case studies of PRAXISKLINIK AM SCHLOSSPARK/Miskawaan Health Group represent carefully & individually assessed clients’ treatments following extensive testing – they are only to be used as examples of treatments and not as a guideline for treatment.