Leukaemia

Leukaemia is a cancer which starts in blood-forming tissue, usually the bone marrow. It leads to the over-production of abnormal white blood cells, the part of the immune system which defends the body against infection. LEUKAEMIA CARE

Background

male-intro@2x-8

Male age 53

Health Concerns

Leukaemia

Background

Three years ago, patient suffered from an infection with fever and multiple severe throat pain.

From a normal routine body check-up, he is found to have a conspicuous white blood cell count.

Leukaemia BG

Diagnosis

Hairy Cell Leukaemia (HCL) is identified in patient

Hairy Cell Leukaemia is a rare and slow-growing blood cancer. It occurs when there is a heavy infiltration in bone marrow, spleen and liver by leukemic cells. Vazzana et al., 2004; Swerdlow, 2008Under the microscope, it shows the patient has developed hairy cell leukaemia and almost no platelets are observed at the darkfield.

The proliferation of these abnormal leukemic cells reduce the generation of healthy white blood cells, red blood cell and platelets.

leukemia virus

High B cell co-expressions & low granulocytes co-expression

B cells are important component of adaptive immunity by producing and secreting millions of different antibody molecules and each of these antibodies recognize a foreign antigen. Ollila & Vihinen, 2005

Patient’s B cells clonal expansions of CD19+ and CD20+ are 99% which is extremely high.

High expression of CD19+ and CD20+ is associated with hairy cell leukaemia. Ginaldi et al., 1998; Troussard & Cornet, 2017

The 1% granulopoese co-expression of CD14+ indicates the patient is low in granulocytes which is a type of white blood cell.

Consequently weakens the patient’s innate immune system.

Increased thrombocytes by 17 %.

Thrombocytes help to form blood clots to slow or stop bleeding and facilitate wounds to heal. National Cancer Institute, 2018

The normal range of thrombocytes are between 140–400 TSND/μl.

Before Treatment – June 2017

Patient’s thrombocytes are less than half of the benchmark: 76 TSND/μl.

During Treatment – August 2017

2 months later, number of thrombocytes increased by 17%: 89 TSND/μl.

After Treatment – October 2017

As patient is not following on the medication and supplement intake instructions, his number of thrombocytes drop back to roughly the same as initial measurement.

Lowered Ebstein Barr Virus (EBV) by 2774.9 times within a year

It was found to be the first virus that cause cancer in human. It is associated with a wide range of human cancers from epithelial cells, lymphocytes and mesenchymal cells.
THOMPSON & KURZROCK, 2004; KO, 2015

Before Treatment – June 2017

The concentration of Ebstein Barr Virus is found very high in patient’s saliva; 1060000 Kop/ml. It is 353 times more than the maximum for normal people.

This type of virus encourages tumour development.

Not Following Medication & Supplement Intake

During Treatment – February 2018

Patient’s EBV concentration still remains very high.

During Treatment – March 2018

Following strictly to Dr. Wessolly’s advice, Patient’s EBV reduced by 802.4 times from 7960000 to 9920 Kop/ml within a month.

After Treatment – May 2018

EBV concentration has reduced to 382 Kop/ml which is within the normal. Compared to the EBV concentration before treatment, it has reduced 2774.9 times.

Treatment & Outcome

Treatment


6 types of supplements
1 type of anti-viral drug
Ketogenic diet

Outcome


Increased number of 
thrombocytes by 17%.
Reduced Ebstein Barr Virus by 2774.9 times within a year.

Summary


Improved white blood cell profile by increasing the number of thrombocytes.
Reduce severity of hairy cell leukemia.

Epstein-Barr Virus (EBV)
It was found to be the first virus that cause cancer in human. It is associated with a wide range of human cancers from epithelial cells, lymphocytes and mesenchymal cells. (Thompson & Kurzrock, 2004; Ko, 2015)

B cells

They are important component of adaptive immunity by producing and secreting millions of different antibody molecules. Each of these antibodies recognize a foreign antigen. (Ollila & Vihinen, 2005)

Natural killer (NK) cells

They are effector lymphocytes of the innate immune system that control a number of tumour types and microbial infections by limiting their spread and subsequent tissue damage. (Vivier et al, 2008; Wu & Lanier, 2003)

TKTL1
It is a marker for anaerobic glucose metabolism which is concomitant with invasive growth/ metastasis, and resistance to radical and apoptosis inducing therapies. 

COY, X2017; GRIMM ET AL, 2013

T-cell Count
It is a blood test that measures the number of T cells and other associated immune cells in the body. T cell is a type of white blood cell that respond to viral infections and boost immune function.

Low T-cell count usually indicates there is problem with the body’s immune system or lymph nodes. MARTEL, 2018

It is also found that cancer patients with low immune cells, such as T cells, are associated with decreased overall survival. MADU ET AL, 2013

References

Advanced Cancer Research (2003) Natural killer cells and cancer
https://www.ncbi.nlm.nih.gov/pubmed/14710949

American Cancer Society (2016) Viruses that can lead to cancer
https://www.cancer.org/cancer/cancer-causes/infectious-agents/infections-that-can-lead-to-cancer/viruses.html

Billett, H.H. (1990) Haemoglobin and haematocrit. Clinical methods: the history, physical, and laboratory examinations
https://www.ncbi.nlm.nih.gov/books/NBK259/

Campo, E., Swerdlow, S.H., Harris, N.L., Pileri, S., Stein, H., Jaffe, E.S. (2011) The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Journal of American Society of Hematology. 117(19):5019-5032
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109529/#

Coy, J.F. (2017) EDIM-TKTL1/Apo10 blood test: an innate immune system based liquid biopsy for the early detection, characterization and targeted treatment of cancer. International Journal of Molecular Sciences. 20:18(4)
https://www.ncbi.nlm.nih.gov/pubmed/28425973

Encyclopaedia Britannica (2019) Neurotransmitter

https://www.britannica.com/science/neurotransmitter

Ginaldi, L., Martinis, M.D., Matutes, E., Farahat, N., Morilla, R., Catovsky, D. (1998) Levels of expression of CD19 and CD20 in chronic B cell leukaemias. Journal Clinica of Pathology. 51:364-369
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC500695/pdf/jclinpath00266-0020.pdf

Grimm, M., Schmitt, S., Teriete, P., Biegner, T., Stenzl, A., Hennenlotter, J., Muhs, H.J., Munz, A., Nadtotschi, T., Konig, K., Sanger, J., Feyen, O., Hofmann, H., Reinert, S., Coy, J.F. (2013) A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells. BMC Cancer. 4:13:569 https://www.ncbi.nlm.nih.gov/pubmed/24304513

Ko, Y.H. (2015) EBV and human cancer. Experimental & Molecular Medicine. 47(1):e130 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314581/

Lange, C.A.K, Tisch-Rottensteiner, J., Bohringer, D., Gottfried, M., Schwartzkopff, J., Auw-Hadrich, C. (2012) Enhanced TKTL1 expression in malignant tumours of the ocular adnexa predicts clinical outcome. Ophthalmology. 119(9):1924- 9
https://www.ncbi.nlm.nih.gov/pubmed/22658715

Madu, A.J., Ocheni, S., Ibegbulam, OG., Aguwa, E.N., Madu, K.A. (2013) Pattern of CD4 T-lymphocyte values in cancer patients on cytotoxic therapy. Annals of Medical and Health Science Research. 3(4):498-503
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868113/

Martel, J. (2018) Healthline: T cell count
https://www.healthline.com/health/t-cell-count

National Cancer Institute (2018) NCI Dictionary of Cancer Terms- cancer

https://www.cancer.gov/publications/dictionaries/cancer-terms/def/cancer

National Cancer Institute (2018) NCI Dictionary of Cancer Terms – complete blood count
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/complete-blood-count

National Cancer Institute (2018) NCI Dictionary of Cancer Terms – malignancy

https://www.cancer.gov/publications/dictionaries/cancer-terms/def/malignancy

National Cancer Institute (2018) NCI Dictionary of Cancer Terms – thrombocytes
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/thrombocyte

National Kidney Foundation (2017) Creatinine: what is it?
https://www.kidney.org/atoz/content/what-creatinine

Ollila, J. & Vihinen, M (2005) B cells. The International Journal of Biochemistry & Cell Biology. 37(3):518-23
https://www.ncbi.nlm.nih.gov/pubmed/15618007

Thompson, M.P. & Kurzrock, R. (2004) Epstein-Barr virus and cancer. Clinical Cancer Research. 10(3):803-21 https://www.ncbi.nlm.nih.gov/pubmed/14871955

Troussard, X., Cornet, E. (2017) Hairy cell leukemia 2018: update on diagnosis, risk stratification, and treatment. American Journal of Hematology 92(12):1382-1390

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698705/

Wu, J., Lanier, L.L. (2003) Natural killer cells and cancer. Advances in Cancer Research. 90:127-56 https://www.ncbi.nlm.nih.gov/pubmed/14710949

University of Rochester Medical Center (2019) What are red blood cells?

https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentID=34&ContentTypeID=160

Vazzana, N., Spadano, R., Sestili, S., Toto, V., Falorio, S., Catinella, V., Angrilli, F., Dragani, A. (2004) Hairy cell leukaemia and venous thromboembolism: a case report and review of the literature. Blood Transfusion. 12(2):276- 279
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039712/

Viver, E., Tomasello, E., Baratin, M., Walzer, T., Ugolini, S. (2008) Functions of natural killer cells. Nature Immunology. 9(5):503-10
https://www.ncbi.nlm.nih.gov/pubmed/18425107

Advanced Cancer Research (2003) Natural killer cells and cancer
https://www.ncbi.nlm.nih.gov/pubmed/14710949

American Cancer Society (2016) Viruses that can lead to cancer
https://www.cancer.org/cancer/cancer-causes/infectious-agents/infections-that-can-lead-to-cancer/viruses.html

Billett, H.H. (1990) Haemoglobin and haematocrit. Clinical methods: the history, physical, and laboratory examinations
https://www.ncbi.nlm.nih.gov/books/NBK259/

Campo, E., Swerdlow, S.H., Harris, N.L., Pileri, S., Stein, H., Jaffe, E.S. (2011) The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Journal of American Society of Hematology. 117(19):5019-5032
https://www.ncbi.nlm.nih.gov/pmc/articles/
PMC3109529/#

Coy, J.F. (2017) EDIM-TKTL1/Apo10 blood test: an innate immune system based liquid biopsy for the early detection, characterization and targeted treatment of cancer. International Journal of Molecular Sciences. 20:18(4)
https://www.ncbi.nlm.nih.gov/pubmed/28425973

Encyclopaedia Britannica (2019) Neurotransmitter
https://www.britannica.com/science/
neurotransmitter

Ginaldi, L., Martinis, M.D., Matutes, E., Farahat, N., Morilla, R., Catovsky, D. (1998) Levels of expression of CD19 and CD20 in chronic B cell leukaemias. Journal Clinica of Pathology. 51:364-369
https://www.ncbi.nlm.nih.gov/pmc/articles/
PMC500695/pdf/jclinpath00266-0020.pdf

Grimm, M., Schmitt, S., Teriete, P., Biegner, T., Stenzl, A., Hennenlotter, J., Muhs, H.J., Munz, A., Nadtotschi, T., Konig, K., Sanger, J., Feyen, O., Hofmann, H., Reinert, S., Coy, J.F. (2013) A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells. BMC Cancer. 4:13:569 https://www.ncbi.nlm.nih.gov/pubmed/24304513

Ko, Y.H. (2015) EBV and human cancer. Experimental & Molecular Medicine. 47(1):e130 https://www.ncbi.nlm.nih.gov/pmc/articles/
PMC4314581/

Lange, C.A.K, Tisch-Rottensteiner, J., Bohringer, D., Gottfried, M., Schwartzkopff, J., Auw-Hadrich, C. (2012) Enhanced TKTL1 expression in malignant tumours of the ocular adnexa predicts clinical outcome. Ophthalmology. 119(9):1924- 9
https://www.ncbi.nlm.nih.gov/pubmed/22658715

Madu, A.J., Ocheni, S., Ibegbulam, OG., Aguwa, E.N., Madu, K.A. (2013) Pattern of CD4 T-lymphocyte values in cancer patients on cytotoxic therapy. Annals of Medical and Health Science Research. 3(4):498-503
https://www.ncbi.nlm.nih.gov/pmc/articles/
PMC3868113/

Martel, J. (2018) Healthline: T cell count
https://www.healthline.com/health/t-cell-count

National Cancer Institute (2018) NCI Dictionary of Cancer Terms- cancer

https://www.cancer.gov/publications/
dictionaries/cancer-terms/def/cancer

National Cancer Institute (2018) NCI Dictionary of Cancer Terms – complete blood count
https://www.cancer.gov/publications/
dictionaries/cancer-terms/def/complete-blood-count

National Cancer Institute (2018) NCI Dictionary of Cancer Terms – malignancy
https://www.cancer.gov/publications/
dictionaries/cancer-terms/def/malignancy

National Cancer Institute (2018) NCI Dictionary of Cancer Terms – thrombocytes
https://www.cancer.gov/publications/
dictionaries/cancer-terms/def/thrombocyte

National Kidney Foundation (2017) Creatinine: what is it?
https://www.kidney.org/atoz/content/what-creatinine

Ollila, J. & Vihinen, M (2005) B cells. The International Journal of Biochemistry & Cell Biology. 37(3):518-23
https://www.ncbi.nlm.nih.gov/pubmed/
15618007

Thompson, M.P. & Kurzrock, R. (2004) Epstein-Barr virus and cancer. Clinical Cancer Research. 10(3):803-21 https://www.ncbi.nlm.nih.gov/pubmed/
14871955

Troussard, X., Cornet, E. (2017) Hairy cell leukemia 2018: update on diagnosis, risk stratification, and treatment. American Journal of Hematology 92(12):1382-1390
https://www.ncbi.nlm.nih.gov/pmc/articles/
PMC5698705/

Wu, J., Lanier, L.L. (2003) Natural killer cells and cancer. Advances in Cancer Research. 90:127-56 https://www.ncbi.nlm.nih.gov/pubmed/
14710949

University of Rochester Medical Center (2019) What are red blood cells?
https://www.urmc.rochester.edu/encyclopedia/
content.aspx?ContentID=34&ContentTypeID=160

Vazzana, N., Spadano, R., Sestili, S., Toto, V., Falorio, S., Catinella, V., Angrilli, F., Dragani, A. (2004) Hairy cell leukaemia and venous thromboembolism: a case report and review of the literature. Blood Transfusion. 12(2):276- 279
https://www.ncbi.nlm.nih.gov/pmc/articles/
PMC4039712/

Viver, E., Tomasello, E., Baratin, M., Walzer, T., Ugolini, S. (2008) Functions of natural killer cells. Nature Immunology. 9(5):503-10
https://www.ncbi.nlm.nih.gov/pubmed/
18425107

* The case studies of PRAXISKLINIK AM SCHLOSSPARK/Miskawaan Health Group represent carefully & individually assessed clients’ treatments following extensive testing – they are only to be used as examples of treatments and not as a guideline for treatment.