Peptides, What Are They and Why Should You Consider Them?

How can Peptides be used to improve health?


What is a Peptide?


First of all, a Peptide is not a steroid.

At the molecular level, a Peptide is a molecule formed by joining between two to fifty amino acids (basic building blocks of the body) together with peptide bonds, with larger sequences of amino acids referred to as proteins. In the body, they manifest as enzymes, hormones, antibiotics, and receptors. They are in all living cells and play a crucial role in various physiological and biochemical functions for life.

Peptides can be of animal origin or synthetic.

What can peptide supplementation be used for?


Supplementing peptides can have a wide range of effects, and this will depend on the peptides that are taken. Some are used for increasing energy, burning fat, building muscle, treating disorders, reducing inflammation and improving athletic ability, or improving cognitive ability.

Types of Peptides


There are many kinds of peptides, which work on different areas of the body. Some of these include:

Weight loss:

  • GHRH - there are several GHRH (Growth Hormone Releasing Hormone) as well as GHRP's that have profound effects on fat loss.
  • AOD-9604 - may target abdominal fat specifically.
  • Tesofensine - a non-peptide appetite suppressant.
  • TTA - a non-peptide molecule that can enhance fat burning by activating PPARa in fat cells.
Healing and Repair:

  • BPC-157- profound impact on musculoskeletal healing and resistance to injury. Also highly effective in gut healing and neuroprotection.
  • Thymosin Beta - a peptide that is one of the first upregulated naturally after an injury. Promotes fast healing and repair.
Neurological Health and Cognitive Enhancement:

  • Cerebrolysin - currently being studied in Alzheimer's and Parkinson's. Fights depression and improves anxiety. Great for post head injury.
  • Selank- anti-anxiety. Increase learning & memory.
  • Semax - Studies showing significant benefits in AD, PD, ALS, and ADHD. It increases memory, learning ability, and even physical performance. It has an anti-inflammatory effect in the brain as well.
  • FGL and DiHexa - both are showing amazing results in neuro-regeneration.
  • Epitalon, NAD+ and BDNF.
Immunity:

  • Thymosin alpha - immune system reboot and enhancement.
  • Melanotan 2 - known for its ability to cause skin tanning. Gaining clinical use in the area of treating CIRS (from chronic mold & Lyme).
  • VIP- helps to rid the body of infections and biotoxins.
Longevity:

  • Epitalon - several human studies are confirming a profound impact on youthful longevity.
Sports and Endurance:

  • MOTS-c - a new peptide that is a replication of a peptide produced by mitochondrial DNA. Showing a significant effect on mitochondrial biogenesis.
Hair growth:

  • PTD-BDM w/ valproic acid - a newly discovered peptide that is showing profound hair regrowth.

How they work


Let's take the example of Growth Hormone Releasing Hormone (GHRH), as mentioned above. Simply put, this peptide stimulates the Hypothalamus to naturally release more Human Growth Hormone (HGH) into the bloodstream. HGH acts on many tissues throughout the body to stimulates the growth of bone and cartilage, boosts protein production, promotes the utilization of fat, interferes with the action of insulin, and raises blood sugar levels. It also helps in the development of lean muscle mass, thereby potentially assisting in lessening the effects of ageing.

Benefits of Peptides (that promote Human Growth Factor)


There is evidence supporting the positive effects of increased Human Growth Hormone. They have included:

  • Protection from fractures,
  • Increased muscle mass,
  • Decreased body fat,
  • Improved exercise capacity and energy
  • Reduced risk of future heart disease.
  • Improvements in psychological well-being,
  • Improved sleep quality

Peptides do require longer treatment times before results are seen than steroids and testosterone, but these come with their potential for negative side effects.

Peptide Side Effects


They can have potentially serious side effects, so it is recommended to consult with your doctor before adopting their use.

Side effects can include:

  • Itchiness at the injection area
  • Increased water retention (a common sign of overdosage)
  • Increased hunger
  • Dry mouth
  • Tingling or numbness
  • High blood pressure
  • Extreme kidney pain
  • Joint pain
  • Darkening of moles and increase of freckles
  • Weight gain/loss
  • Decreased fertility

Are they safe to take?


It depends on how much you are taking, what it is, and your own personal health and medical circumstances. As with anything you put into your body, it is advised to consult with your medical doctor before taking any form of peptide or treatment to make sure that it is right for you.

Peptides treatments help your body to maintain the biological processes that it usually would do. Due to a fantastic safety profile and the true bio-specific precision of the approach, peptides are in a strong position to become an acceptable treatment tool, overtaking pharmaceuticals in the years ahead.

Although their use has prompted discussion and is somewhat controversial, research into peptides has been going on for decades and is a continuously growing field of science. Currently, there are 1000's of current peptides that are undergoing animal and human testing.

Peptides in Conventional Medicine


Biochemists are also very excited by the possibilities presented by peptides as pharmaceuticals because they often mimic the behaviour of a natural ligand. This substance interacts with the receptor on an enzyme or cell to cause a biological process. This gives peptide drugs the potential to be more precisely targeted, with fewer side effects than conventional medications.

Currently, in the USA, there are around 60 FDA-approved peptide drugs on the market, with about 140 peptide drugs in clinical trials, and over 500 in pre-clinical (before human testing) development. One of the best-known peptide-based drugs is Exenatide, which is marketed under the name Byetta. It's used to help control blood sugar levels in type 2 diabetes patients.

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How Do You Take Peptides?


Peptides are typically injected into the body, although researchers are working on developing other methods for introducing peptides into the body. These include transdermal patches and creams.

Should You Use Peptides?


When determining what you want to put in your body, you must always ask whether the benefits outweigh the side effects. Don't buy cheap online products, and always ask your doctor before taking them.

Some questions to ask yourself and your doctor


  • What do you want to achieve, and why do you want to use it?
  • What are the risks, and do the benefits outweigh them?
  • Is it legal (this will depend on the jurisdiction, so check)?
  • Which are the right ones for you to take to achieve your goals?

Miskawaan Health Group offers a range of peptide and peptide-based therapies. Please make an appointment for a consultation with our doctors to discuss if they can be of benefit to your health.

Additional Sources


https://imb.uq.edu.au/article/2017/11/explainer-peptides-vs-proteins-whats-difference

https://vimeo.com/327588475/597e5cac31.

The Truth About Using Peptides & How They Impact Your Health

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775681/

AICAR: the couch potato pill

https://selfhacked.com/blog/sr9009-stenabolic/

https://www.sciencedaily.com/releases/2019/10/191003074825.htm

https://www.ncbi.nlm.nih.gov/pubmed/11713213

The fat-burning truth about AOD 9604

https://www.foundmyfitness.com/episodes/nad-nr-nmn

https://www.foundmyfitness.com/topics/nad

https://www.foundmyfitness.com/episodes/igf-1-stem-cells-refeeding

https://www.jneurology.com/articles/recent-advances-in-the-biology-of-bdnf-and-the-newly-identified-propeptide.html

https://www.christopherreeve.org/blog/research-news/bdnf-exercise-good-can-i-take-a-pill-instead

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